There is no doubt that physical exercise is mostly good for your health and the list of benefits it provides grows with ever more studies being published. It is also helpful for the funding of research to understand the health benefits of exercise in detail, namely the molecules and metabolic and regulatory pathways that translate a workout into a healthier body. A major aim of this research was to identify key elements that could be manipulated using drugs to mimic the health benefits of physical activity: “exercise in a bottle”. Such a replacement for the “real thing” might sound rather frivolous, but it would offer a therapeutic option for people who are unable to engage in sufficient physical activity, for whatever reason. It could, for instance, kick‐start a recovery program for morbidly obese people, or for patients with severe injuries, at least until they are able to start exercising on their own. Most research has focused on the impact of exercise on the metabolism of glucose and lipids for energy, along with insulin production and sensitivity, as these directly affect body weight, muscle and fat tissue and blood sugar levels. But physical activity also has a demonstrated positive effect on bone density and cognitive function. It can improve the outcome of cancer treatment and therapies for some autoimmune disorders, such as rheumatoid arthritis, as it dampens inflammatory reactions in the body. Lastly, exercise of course benefits the whole body, for example by strengthening the cardiovascular and skeletomuscular system.
MOTS-c is a peptide of 16 amino acids that promote metabolic balance. It regulates metabolic functions throughout the body. For instance, it turns glucose into usable energy. The DNA in the cell nucleus encodes most peptides. But the mitochondria’s DNA encodes MOTS-c making it unique among peptides. Research by the University of Southern California found this peptide may help fight weight gain and normalize metabolism – similar to effects mostly linked with exercise. In studies, the peptide aided glucose metabolism, even when eating a high-fat diet. These initial studies could indicate improved blood sugar control for those with obesity and type 2 diabetes.
MOTS-c Effects, Functions, and Traits
Humans evolved to have flexible metabolism. Meaning we can adapt according to energy supply and demand. Our bodies store the optimal amounts of amino acids, fatty acids, and glucose to use during food shortages or times with higher energy demand. But, eating excess calories and processed food regularly and inactivity causes metabolic inflexibility and dysfunction. Dysfunctional metabolism may cause weight gain in various ways because they:
• Stops muscles from using fats instead of carbohydrates for energy demands.
• Impairs the body’s ability to manage food intake and energy use.
• Distorts the body’s ability to recognize nutrients and respond suitably, as is the case with insulin resistance.
Besides optimal mitochondria function, our bodies need proper energy intake and use, as well as glucose and insulin control, to stay healthy. And, because mitochondria control metabolism on a cellular level, fixing the mitochondria may improve the metabolism.
How MOTS-c May Help
MOTS-c has a long list of possible benefits. Most notably, it may improve physical function, insulin sensitivity, age-related metabolic diseases, and obesity.
Improves Physical Function
One of the signs of aging is the gradual loss of cell function. In turn, this inhibits the working tissue of organs and leads to less physical ability. As a result, aging is the leading risk for chronic disease.
We link aging with reduced MOTS-c levels in many tissues, including skeletal muscle and circulation.
According to study results, MOTS-c treatment helped significantly longer and further than untreated patients. What’s more, patients outperformed untreated patients. The results suggest physical re-programming rather than just rejuvenation.
In other words, MOTS-c seems to increase exercise ability on a cellular level.
Controls Insulin Sensitivity
MOTS-c may also improve whole-body insulin sensitivity.
When there’s more glucose available, insulin helps distribute it. It also inhibits hepatic glucose production (HGP) to help the body maintain balance.
As the body becomes less sensitive to insulin, it doesn’t use it as well, which increases the risk of type 2 diabetes.
Researchers noted the peptide helped the body distribute insulin faster, showing better skeletal muscle insulin sensitivity.
Because MOTS-c boosts insulin sensitivity, it may help the body use insulin better and lower the risk of insulin resistance.
of Aging We associate aging with a decline of mitochondrial function and developing age-related diseases, such as diabetes and metabolic syndrome. And since MOTS-c levels fall with age, declining mitochondrial-derived peptides (MDP) may relate to metabolic decline. Thus, regular MDP treatments may improve the abnormal metabolism linked with aging in humans.
Helps with Diet-induced Obesity
The peptide helps activate AMPK in mice on a high-fat diet. For this reason, it may prevent diet-induced obesity. What is AMPK? The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Cells activate AMPK when they are running low on energy. It’s also activated throughout the body after exercise or during calorie restriction. Studies show that compounds that activate AMPK may promote health. For instance, it may reverse diabetes, enhance heart health, treat mitochondrial diseases, and even increase life span. Increases oxygen and glucose more efficiently and generated more heat. As a result, they burned more energy. The study suggests that MOTS-c may prevent diet-induced obesity because it increases energy use and heat production and improves insulin sensitivity and glucose use.
In addition to the benefits mentioned, it may also:
• Promote fatty acid metabolism in the liver
• Help control mitochondrial energy
• Promote metabolic flexibility and balance
• Improve resistance to metabolic stress
• Help prevent osteoporosis
Suggested dosage for vile size of: 5mg Suggested Frequency of use: 5 times per week – take in the morning preferably before noon
Where to inject: Injected into the body fat around the stomach area.
Suggested Injection Dosage per time: 20iu (20 Units)
What Type of water to mix with? Bacteriostatic Water
How much water to add: 2cc (2ML)